AT1R antagonist 4

AT1R antagonist 4 (Example 26) is an AT1R antagonist. AT1R antagonist 4 shows excellent antagonistic activity against calcium influx in cells stably expressing AT1 receptors and ETA receptors. AT1R antagonist 4 can be used in kidney disease research[1].

Product Specifications

CAS Number

[2982582-16-9]

UNSPSC

12352005

Target

Angiotensin Receptor; Calcium Channel; Endothelin Receptor

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Endocrinology

Smiles

O=C1NC(C2=C1C(Br)=CC=C2NS(=O)(C3=CC(C#CC4=NOC(C)=C4C)=CC=C3)=O)O

Molecular Formula

C21H16BrN3O5S

Molecular Weight

502.34

References & Citations

[1]Zhong, et al. Alkynyl-containing condensed ring derivative antagonist, preparation method and application thereof. CN116675684A. China. 2023-08-02.