Antitumor agent-208

Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM) . Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

[1385011-94-8]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(C=C4)=COC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)OC(NC6CCNCC6)=O)([H])CC3)C

Molecular Formula

C30H44N2O5

Molecular Weight

512.68

References & Citations

[1]Lei M, et al. Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents. Steroids. 2016 Apr;108:56-60.