Antitumor agent-208
Antitumor agent-208, a Bufalin analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC).
Product Specifications
CAS Number
1385011-94-8
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(C=C4)=COC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)OC(NC6CCNCC6)=O)([H])CC3)C
Molecular Formula
C30H44N2O5
Molecular Weight
512.68
References & Citations
[1]Lei M, et al. Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents. Steroids. 2016 Apr;108:56-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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