Trimethidinium (methosulfate)

Trimethidinium methosulfate is an orally active ganglionic blocker with central antihypertensive activity. Trimethidinium methosulfate inhibits the conduction of sympathetic ganglia and reduces vascular contraction. Trimethidinium methosulfate acts on the cerebrovascular motor center and lowers peripheral vascular resistance. Trimethidinium methosulfate has cholinergic nerve inhibitory side effects, but they are relatively mild. Trimethidinium methosulfate can be used in hypertension research[1][2].

Product Specifications

CAS Number

[14149-43-0]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=S([O-])(OC)=O.CC1(C2CCC1(C[N+](CCC[N+](C)(C)C)(C2)C)C)C.O=S([O-])(OC)=O

Molecular Formula

C19H42N2O8S2

Molecular Weight

490.68

References & Citations

[1]PELNER L, WALDMAN S. Trimethidinium methosulfate in the treatment of moderate and severe hypertension. J Am Geriatr Soc. 1960 Mar;8:168-76. |[2]BORHANI NO. Use of trimethidinium methosulfate (a new ganglionic blocking agent) in the treatment of hypertension. Ann Intern Med. 1959 Nov;51:983-92.