Graviquinone

Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research[1].

Product Specifications

CAS Number

1383995-51-4

UNSPSC

12352211

Target

Checkpoint Kinase (Chk) ; Reactive Oxygen Species (ROS)

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

COC(/C=C/C1(C=CC(C=C1)=O)O)=O

Molecular Formula

C10H10O4

Molecular Weight

194.18

References & Citations

[1]Fási L, et al. Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. J Med Chem. 2019 Feb 14;62 (3) :1657-1668.