KFP-H008
KFP-H008 is an orally active potassium-competitive acid blocker. KFP-H008 inhibits gastric acid secretion through blocking H+-K+-ATPase. KFP-H008 reduces ethanol-induced gastric ulcer index and malonaldehyde as well as proinflammatory cytokine expression in vivo. KFP-H008 downregulates p-p38 MAPK and p65 NF-κB expression. KFP-H008 blocks histamine-stimulated acid secretion in rat and dog models. KFP-H008 can be studied in research on acid-related disease, such as ethanol-induced gastric ulcer and gastric epithelial cell damage[1][2][3].
Product Specifications
CAS Number
[1876453-55-2]
UNSPSC
12352005
Target
ATP Synthase; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Smiles
O=S(=O)(C=1C=NC=CC1)N2C=C(C=C2C3=CC=C4NC=CC4=C3)CNC
Molecular Formula
C19H18N4O2S
Molecular Weight
366.44
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-180348/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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