Hepta-histidine
Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease[1][2].
Product Specifications
CAS Number
[64134-31-2]
UNSPSC
12352005
Target
Huntingtin
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
[C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CN=CN4)C(O)=O)=O)=O)=O)NC([C@H](CC5=CN=CN5)NC([C@H](CC6=CN=CN6)NC([C@H](CC7=CN=CN7)N)=O)=O)=O
Molecular Formula
C42H51N21O8
Molecular Weight
978.01
References & Citations
[1]Kondo K, et al., Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021 Aug 18;12 (16) :3015-3027.|[2]Imamura T, et al., Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22;6:33861.
Shipping Conditions
Room temperature
Scientific Category
Reference compound
Clinical Information
No Development Reported
Curated Selection
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