NEPP11
NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].
Product Specifications
CAS Number
313051-12-6
UNSPSC
12352005
Target
Apoptosis; Drug Derivative; ERK; Keap1-Nrf2; MEK; Raf
Related Pathways
Apoptosis; MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
Molecular Formula
C26H36O3
Molecular Weight
396.57
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
C-Raf; ERK1; ERK2; MEK1; MEK2
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