NEPP11

NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].

Product Specifications

CAS Number

[313051-12-6]

UNSPSC

12352005

Target

Apoptosis; Drug Derivative; ERK; Keap1-Nrf2; MEK; Raf

Related Pathways

Apoptosis; MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2

Molecular Formula

C26H36O3

Molecular Weight

396.57

References & Citations

[1]Shibata S, et al. Prevention of oxytosis-induced c-Raf down-regulation by (arylthio) cyclopentenone prostaglandins is neuroprotective. Toxicology. 2017 Sep 1;390:83-87.