NAT6-297775
NAT6-297775 (Compound 29) is a protein tyrosine phosphatase (PTP) inhibitor targeting non-receptor PTP SHP-2 with an IC50 of 2.5 μM. NAT6-297775 can inhibit the RAS/MAP kinase signaling pathway. NAT6-297775 can be used for the research of cancer, such as leukemia[1].
Product Specifications
CAS Number
[1348433-02-2]
UNSPSC
12352005
Target
Phosphatase; SHP2
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N(CC1CCCCC1)[C@H]2O[C@@]3([C@H](CO[C@@]3(C2)[H])N4C(=NN=N4)C5=CC(CN6CCCC6)=CC=C5)[H]
Molecular Formula
C25H36N6O2
Molecular Weight
452.60
References & Citations
[1]Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19 (7) :2145-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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