DDC4002
DDC4002 is a selective EGFR inhibitor. DDC4002 has inhibitory activity against the L858R/T790M mutant EGFR subtype (IC50 = 39 nM) [1].
Product Specifications
CAS Number
[2375048-04-5]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Others
Smiles
O=C1C=2C=CC=CC2NC3=CC=C(F)C=C3N1CC=4C=CC=CC4
Molecular Formula
C20H15FN2O
Molecular Weight
318.35
References & Citations
[1]De Clercq DJH, et al. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. ACS Med Chem Lett. 2019 Oct 22;10 (11) :1549-1553.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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