Candidone

Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA[1][2][3].

Product Specifications

CAS Number

[77727-18-5]

UNSPSC

12352005

Target

Apoptosis; Bacterial; Bcl-2 Family; Caspase; DNA/RNA Synthesis; MMP; p38 MAPK; Survivin

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Smiles

COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C

Molecular Formula

C22H24O4

Molecular Weight

352.42

References & Citations

[1]Boonyarat C, et al. Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells. Biol Pharm Bull. 2021 Apr 1;44 (4) :494-500. |[2]Kurasug B, et al. Antitumor effects of candidone extracted from Derris indica (Lamk) Bennet in cholangiocarcinoma cells. Tropical Journal of Pharmaceutical Research. 2018;17 (7) :1337-43.|[3]Dehkordi MF, et al. The interaction mechanism of candidone with calf thymus DNA: A multi-spectroscopic and MD simulation study. Int J Biol Macromol. 2023 Apr 30;235:123713.