TG2-IN-3h
TG2-IN-3h (Compound 3h) is a transglutaminase (TG2) inhibitor (hTG2: IC50 = 6nM) . TG2-IN-3h inhibits endothelial cell migration and angiogenesis. TG2-IN-3h alleviates renal fibrosis in a mouse model of hypertensive nephropathy. TG2-IN-3h can be used in research on metabolic diseases such as hypertensive nephropathy and cardiovascular and cerebrovascular diseases such as pathological angiogenesis[1].
Product Specifications
CAS Number
[1592640-75-9]
UNSPSC
12352005
Target
Glutaminase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
O=C(C=C)NCC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=CC=3C2=CC=CC3N(C)C
Molecular Formula
C21H26N4O4S
Molecular Weight
430.52
References & Citations
[1]Badarau E, et al. Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol. 2015 Oct 22;22 (10) :1347-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1312077-01 0.02 mg (E-Coli)
Recombinant Francisella tularensis subsp. holarctica D-alanine--D-alanine ligase (ddl)
Ask
View Details MBS1312077-02 0.02 mg (Yeast)
Recombinant Francisella tularensis subsp. holarctica D-alanine--D-alanine ligase (ddl)
Ask
View Details MBS1312077-03 0.1 mg (E-Coli)
Recombinant Francisella tularensis subsp. holarctica D-alanine--D-alanine ligase (ddl)
Ask
View Details