Antibacterial agent 309

Antibacterial agent 309 (Compound C9) is an antibacterial agent, substrate of AcrB efflux pump. Antibacterial agent 309 promotes FtsZ polymerization. Antibacterial agent 309 demonstrates antibacterial activity against Erythromycin (HY-B0220) -resistant S. pyogenes 2 (MIC = 0.25 μg/mL), Penicillin-resistant S. aureus CI (MIC = 0.125 μg/mL), Penicillin-resistant S. epidermidis (MIC = 2 μg/mL) . Antibacterial agent 309 exhibits weak antibacterial activity against the wild-type E. coli BW25113 MIC = 256 μg/mL) [1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

C[N+]1=C(/C=C/C2=CC=C(F)C=C2)N=C(/C=C3SC(C=CC=C4)=C4N\3C)C5=CC=CC=C51.[I-]

Molecular Formula

C26H21FIN3S

Molecular Weight

553.43

References & Citations

[1]Zhang S, et al. Novel 1-Methylquinazoline and 1-Methylquinoxaline derivatives targeting FtsZ protein: Potent antibacterial agents against gram-positive bacteria. Bioorg Chem. 2025 Dec;167:109282.