ASGPR ligand-2
ASGPR ligand-2 (Compound 366) is an asialoglycoprotein receptor (ASGPR) binder. ASGPR ligand-2 can be coupled with recognition elements of target proteins (such as antibodies or antigen-binding fragments), and through the endocytosis mediated by ASGPR, the target protein is delivered to the lysosomes of liver cells, promoting the degradation of the target protein. ASGPR ligand-2 can be used for the research of metabolic disease[1].
Product Specifications
CAS Number
[3062599-51-0]
UNSPSC
12352005
Target
LYTACs
Related Pathways
PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
[N-]=[N+]=NCCOCCOCCOCC(NCCOCCC(NCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O)=O)=O
Molecular Formula
C27H50N6O14
Molecular Weight
682.72
References & Citations
[1]Wieslaw Kazmierski, et al. Asgpr binders and compositions and methods thereof. WO2024229005A2. 2025-10-30
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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