PROTAC BRD4 Degrader-41

PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; c-Myc; Epigenetic Reader Domain; PROTACs

Related Pathways

Apoptosis; Epigenetics; PROTAC

Field of Research

Cancer

Smiles

CC1=NN=C2[C@H](CC(NCCCCCCCCC(N[C@@H](CCC3=CC=CC=C3)C(NC4CCC(NC4=O)=O)=O)=O)=O)N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N21

Molecular Formula

C43H51ClN8O5S

Molecular Weight

827.43

References & Citations

[1]Huang K, et al. Design, synthesis, and biological evaluation of novel PROTACs based on unnatural dipeptide CRBN ligands. Eur J Med Chem. 2026 Feb 5;303:118387.