PROTAC BRD4 Degrader-41
PROTAC BRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. PROTAC BRD4 Degrader-41 exhibits potent anti-proliferative activity against various types of cancer cells such as AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. PROTAC BRD4 Degrader-41 can induce G0/G1 phase arrest and apoptosis in MV4-11 cells. PROTAC BRD4 Degrader-41 downregulates the transcriptional level of c-Myc[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Myc; Epigenetic Reader Domain; PROTACs
Related Pathways
Apoptosis; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=NN=C2[C@H](CC(NCCCCCCCCC(N[C@@H](CCC3=CC=CC=C3)C(NC4CCC(NC4=O)=O)=O)=O)=O)N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N21
Molecular Formula
C43H51ClN8O5S
Molecular Weight
827.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Cereblon
Frequently Asked Questions
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