PROTAC ALK degrader-4
PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma. (Pink: ALK ligand ; Blue: CRBN ligand (HY-179733) ; Black: linker).
Product Specifications
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; ERK; IGF-1R; PROTACs; STAT
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)CCCCCCCC(NC5(CCC5)C(NC6C(NC(CC6)=O)=O)=O)=O)OC(C)C
Molecular Formula
C46H63ClN8O7S
Molecular Weight
907.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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