CRBN ligand-190
CRBN ligand-190 is a is a CRBN-type E3 ubiquitin ligase ligand, can be used for the synthesis of PROTACs, such as PROTAC HPK1 Degrader-7 (HY-179727) [1].
Product Specifications
CAS Number
[1543013-96-2]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Inflammation/Immunology
Smiles
FC1=CC(N(C(N2)=O)CCC2=O)=CC=C1
Molecular Formula
C10H9FN2O2
Molecular Weight
208.19
References & Citations
[1]Zhang Z, et al. Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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