PROTAC HPK1 Degrader-7
PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; MAP4K; PROTACs
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; PROTAC
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(C4=CN=C5OCCNC5=C4C)C=C3)=O)=C1C)NCCN6CCN(CC7CCN(C8=CC=C(N(C(N9)=O)CCC9=O)C=C8F)CC7)CC6
Molecular Formula
C46H53FN10O5
Molecular Weight
844.98
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1
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