PZ-1129
PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM) . PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder[1].
Product Specifications
CAS Number
1919029-61-0
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=S(NC1CCN(CC1)CCOC2=C(C3=CC=CC=C3)C=CC=C2)(C4=CC=C(C=C4)F)=O
Molecular Formula
C25H27FN2O3S
Molecular Weight
454.56
References & Citations
[1]Canale V, et al. Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy) ethyl-piperidines toward antidepressant and pro-cognitive properties. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118369.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; D2 Receptor
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