GSK3β-IN-4

GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC50 of 0.37 nM. GSK3β-IN-4 shows an IC50 of 2.75 nM and SI of 7.4 for GSK3α. GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease[1].

Product Specifications

CAS Number

[3083425-61-7]

UNSPSC

12352005

Target

GSK-3; Tau Protein

Related Pathways

Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

O=C(C1CCCC1)NC2=C3C(C4=CC=C(C(N[C@@H](C5=CC=CC=C5)C)=O)C=C4N3)=CC=N2

Molecular Formula

C26H26N4O2

Molecular Weight

426.51

References & Citations

[1]Liu W, et al. Discovery of novel harmine derivatives as potent, selective, and brain permeable GSK3β inhibitors with effective In vivo anti-AD activity. Eur J Med Chem. 2026;303:118389.