GSK3β-IN-4
GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC50 of 0.37 nM. GSK3β-IN-4 shows an IC50 of 2.75 nM and SI of 7.4 for GSK3α. GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease[1].
Product Specifications
CAS Number
3083425-61-7
UNSPSC
12352005
Target
GSK-3; Tau Protein
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(C1CCCC1)NC2=C3C(C4=CC=C(C(N[C@@H](C5=CC=CC=C5)C)=O)C=C4N3)=CC=N2
Molecular Formula
C26H26N4O2
Molecular Weight
426.51
References & Citations
[1]Liu W, et al. Discovery of novel harmine derivatives as potent, selective, and brain permeable GSK3β inhibitors with effective In vivo anti-AD activity. Eur J Med Chem. 2026;303:118389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β
Frequently Asked Questions
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