CCKBR agonist-2
CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].
Product Specifications
CAS Number
923714-61-8
UNSPSC
12352005
Target
Cholecystokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=CC(OC)=CC(C(NC2=C(C=CC=C2)O)=O)=C1
Molecular Formula
C15H15NO4
Molecular Weight
273.28
References & Citations
[1]Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674 (25) 01238-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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