WZS0347

WZS0347 is a MITF PROTAC degrader. WZS0347 effectively reduces the MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. WZS0347 can be used for research on melanoma (Pink: MITF ligand: (HY-179718) ; Blue: CRBN ligand: (HY-131717) ; Black: linker: (HY-22391) ) [1].

Product Specifications

UNSPSC

12352005

Target

Microphthalmia Associated Transcription Factor (MITF) ; PROTACs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C(NCCCCCCCNC1=CC(NC(/C=C/C2=CC=CO2)=O)=NC(NC(/C=C/C3=CC=CO3)=O)=C1)CNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O

Molecular Formula

C41H42N8O9

Molecular Weight

790.82

References & Citations

[1]Shen W, et al. Discovery of a first-in-class degrader for microphthalmia-associated transcription factor (MITF) . Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118367.