PROTAC JAK1/2 degrader-1
PROTAC JAK1/2 degrader-1 (Compound A8) is a selective JAK1/2 PROTAC degrader, with DC50 values of 1.4 μM for JAK1 and 0.92 μM for JAK2. PROTAC JAK1/2 degrader-1 significantly inhibits the release of NO, IL-6 (IC50 = 12.89 μM) and TNF-α (IC50 = 17.17 μM). PROTAC JAK1/2 degrader-1 significantly alleviates inflammatory responses and colonic damage by inhibiting the JAK/STAT3 signaling pathway. PROTAC JAK1/2 degrader-1 can be used for research on colitis. (Pink: JAK1/2 ligand ; Blue: CRBN ligand (HY-10984) ; Black: linker; CRBN ligand + linker (HY-131888A) ).
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; JAK; PROTACs; STAT; TNF Receptor
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C(NCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(C5=NC(NC6=CC=CC=C6)=NC=C5)C=C4
Molecular Formula
C33H29N7O5
Molecular Weight
603.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; IL-10; IL-6; JAK1; JAK2; STAT3
Frequently Asked Questions
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