DAM-001
DAM-001 (Z236004662) is a potent, non-competitive allosteric inhibitor for human dopamine transporter (hDAT) with an IC50 of 24.70 μM and 1.026 μM in the absence and presence of orthosteric inhibitor Nomifensine.
Product Specifications
CAS Number
1090396-31-8
Product Name Alternative
Z236004662
UNSPSC
12352005
Target
Dopamine Transporter
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1CCCC1)N(CCC2)CC2C3=NC4=CC=CC=C4N3
Molecular Formula
C18H23N3O
Molecular Weight
297.39
References & Citations
[1]Ye X, et al. Discovery of a new allosteric inhibitor for human dopamine transporter by physics-based modeling and experimental validation. Eur J Med Chem. 2026 Feb 5;303:118403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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