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DAM-001

DAM-001 (Z236004662) is a potent, non-competitive allosteric inhibitor for human dopamine transporter (hDAT) with an IC50 of 24.70 μM and 1.026 μM in the absence and presence of orthosteric inhibitor Nomifensine.

Product Specifications

CAS Number

1090396-31-8

Product Name Alternative

Z236004662

UNSPSC

12352005

Target

Dopamine Transporter

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1CCCC1)N(CCC2)CC2C3=NC4=CC=CC=C4N3

Molecular Formula

C18H23N3O

Molecular Weight

297.39

References & Citations

[1]Ye X, et al. Discovery of a new allosteric inhibitor for human dopamine transporter by physics-based modeling and experimental validation. Eur J Med Chem. 2026 Feb 5;303:118403.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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