D2R/D3R/5-HT1AR agonist 1
D2R/D3R/5-HT1AR agonist 1 (compound 22b) is an orally active triple-target D2R/D3R/5-HT1AR agonist with EC50 values of 1.29, 1.05 and 153.5 nM. D2R/D3R/5-HT1AR agonist 1 can improve the behavioral disorders induced by MPTP and exerts anti-depression effect. D2R/D3R/5-HT1AR agonist 1 can be used for the research of Parkinson's disease and depression[1].
Product Specifications
CAS Number
3028684-07-0
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1CCC(CN([C@@H](CC2)CC3=C2N=C(N)S3)CCC)CC1)N4CCOCC4
Molecular Formula
C21H35N5O2S
Molecular Weight
421.60
References & Citations
[1]Du X, et al. Novel 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole derivatives as triple-target D2R/D3R/5-HT1AR agonists with robust antidepressant and antiparkinsonian activity. Eur J Med Chem. 2026 Feb 5;303:118409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; D2 Receptor; D3 Receptor
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