As-CA11

As-CA11 is a Thioredoxin reductase (TrxR) inhibitor with an IC50 of 18.7 nM. As-CA11 is shows potent inhibitory activities against HeLa, HepG2, A549 and HL-60 cells with IC50 of 0.35, 0.3, 0.43 and 0.28 μM. As-CA11 can induce cancer cells apoptosis and ROS production. As-CA11 can reduce the level of reduced Trx and increase the level of oxidized Trx. As-CA11 demonstrates anti-tumor activity in the 4T1 tumor-bearing mouse model[1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Reactive Oxygen Species (ROS) ; TrxR

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

ClC1=CC=CC(Cl)=C1/C=C/C(NC2=CC=C([As]3SCCCS3)C=C2)=O

Molecular Formula

C18H16AsCl2NOS2

Molecular Weight

472.28

References & Citations

[1]Shi S, et al. Structure-Guided optimization of PAO-PDT yields TrxR inhibitors as potential anticancer agent. Eur J Med Chem. 2026 Feb 5;303:118407.