AChE/BChE-IN-32

AChE/BChE-IN-32 (Compound 4a) is an AChE and BChE inhibitor, with Ki values of 2.48 and 0.696 μM respectively. AChE/BChE-IN-32 inhibits Aβ aggregation and exhibits a strong ABTS•+ scavenging ability (TEAC = 2.40) . AChE/BChE-IN-32 shows significant neuroprotective activity in glutamate and hydrogen peroxide-induced oxidative stress models. AChE/BChE-IN-32 can be used for the study of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC1=C(CNCCCCNC2=C(CCC3)C3=NC4=C2CCCC4)C(CO)=CN=C1C

Molecular Formula

C24H34N4O2

Molecular Weight

410.55

References & Citations

[1]Makhaeva GF, et al. Synthesis, biological evaluation, and in silico studies of pyridoxal-amiridine hybrids as multitargeting anti-Alzheimer's disease agents. Eur J Med Chem. 2026 Feb 5;303:118397.