AChE/BChE-IN-32
AChE/BChE-IN-32 (Compound 4a) is an AChE and BChE inhibitor, with Ki values of 2.48 and 0.696 μM respectively. AChE/BChE-IN-32 inhibits Aβ aggregation and exhibits a strong ABTS•+ scavenging ability (TEAC = 2.40) . AChE/BChE-IN-32 shows significant neuroprotective activity in glutamate and hydrogen peroxide-induced oxidative stress models. AChE/BChE-IN-32 can be used for the study of Alzheimer's disease[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC1=C(CNCCCCNC2=C(CCC3)C3=NC4=C2CCCC4)C(CO)=CN=C1C
Molecular Formula
C24H34N4O2
Molecular Weight
410.55
References & Citations
[1]Makhaeva GF, et al. Synthesis, biological evaluation, and in silico studies of pyridoxal-amiridine hybrids as multitargeting anti-Alzheimer's disease agents. Eur J Med Chem. 2026 Feb 5;303:118397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
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