NDM-1-IN-12
NDM-1-IN-12 (Compound 10c) is an inhibitor of NDM-1 metallo-β-lactamase, with an IC50 value of 9 nM. NDM-1-IN-12 effectively reverses bacterial resistance to β-lactam antibiotics and shows an additive effect when used in combination with antibiotics and SBL inhibitors. NDM-1-IN-12 can be used in the research of anti-multi-drug resistant bacteria[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CN(C)C(C1=CC=C(C2=C(C(O)=O)NC(C3=CC=C(NC(CCN)=O)C=C3)=C2)C=C1)=O
Molecular Formula
C23H24N4O4
Molecular Weight
420.46
References & Citations
[1]Shkuratova TS, et al. Rational design of 1H-pyrrole-2-carboxylic acid inhibitors of NDM-1 metallo-β-lactamase restoring β-lactam efficacy against resistant Enterobacterales. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118376.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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