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NDM-1-IN-12

NDM-1-IN-12 (Compound 10c) is an inhibitor of NDM-1 metallo-β-lactamase, with an IC50 value of 9 nM. NDM-1-IN-12 effectively reverses bacterial resistance to β-lactam antibiotics and shows an additive effect when used in combination with antibiotics and SBL inhibitors. NDM-1-IN-12 can be used in the research of anti-multi-drug resistant bacteria[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CN(C)C(C1=CC=C(C2=C(C(O)=O)NC(C3=CC=C(NC(CCN)=O)C=C3)=C2)C=C1)=O

Molecular Formula

C23H24N4O4

Molecular Weight

420.46

References & Citations

[1]Shkuratova TS, et al. Rational design of 1H-pyrrole-2-carboxylic acid inhibitors of NDM-1 metallo-β-lactamase restoring β-lactam efficacy against resistant Enterobacterales. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118376.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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