Cbz-QFR-kbt

Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM) . Cbz-QFR-kbt can be used in antiviral research[1].

Product Specifications

CAS Number

[3086979-57-6]

UNSPSC

12352005

Target

Factor Xa; Influenza Virus; SARS-CoV; Ser/Thr Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

NC(NCCC[C@@H](C(C1=NC(C=CC=C2)=C2S1)=O)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(N)=O)NC(OCC4=CC=CC=C4)=O)=O)=O)=N

Molecular Formula

C35H40N8O6S

Molecular Weight

700.81

References & Citations

[1]Banas V, et al. Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118385.