FXR agonist 15

FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH) [1].

Product Specifications

CAS Number

[2991276-14-1]

UNSPSC

12352100

Target

FXR

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

FC1=CC(C2=CC=C(N(S(=O)(C3=C(Cl)C=CC=C3Cl)=O)CC(C)C)C=C2)=CC=C1OCC(O)=O

Molecular Formula

C24H22Cl2FNO5S

Molecular Weight

526.40

References & Citations

[1]Wang W, et al. Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists. Eur J Med Chem. 2023;258:115614.