NIK-IN-3
NIK-IN-3 is a potent and orally active NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 5.2 nM. NIK-IN-3 suppresses non-canonical NF-κB pathway activation and inhibits the secretion of pro-inflammatory cytokines, such as TNF-α, IL-6, IL-1β and chemokine CXCL12. NIK-IN-3 shows significant anti-inflammatory effects in LPS -induced sepsis mice model and DSS (HY-116282) -induced colitis model. NIK-IN-3 can be used for the research of inflammation, such as colitis[1].
Product Specifications
UNSPSC
12352005
Target
CXCR; Interleukin Related; NF-κB; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O[C@](C1=NC=CS1)(C)C#CC2=CC=C(N3CCOCC3)C(NC4=CC=NC(NC5=NC=CCl=C5)=N4)=C2
Molecular Formula
C25H24ClN7O2S
Molecular Weight
522.02
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; NF-κB
Frequently Asked Questions
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