NIK-IN-3

NIK-IN-3 is a potent and orally active NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 5.2 nM. NIK-IN-3 suppresses non-canonical NF-κB pathway activation and inhibits the secretion of pro-inflammatory cytokines, such as TNF-α, IL-6, IL-1β and chemokine CXCL12. NIK-IN-3 shows significant anti-inflammatory effects in LPS (HY-D1056) -induced sepsis mice model and DSS (HY-116282) -induced colitis model. NIK-IN-3 can be used for the research of inflammation, such as colitis[1].

Product Specifications

UNSPSC

12352005

Target

CXCR; Interleukin Related; NF-κB; TNF Receptor

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB

Field of Research

Inflammation/Immunology

Smiles

O[C@](C1=NC=CS1)(C)C#CC2=CC=C(N3CCOCC3)C(NC4=CC=NC(NC5=NC=CCl=C5)=N4)=C2

Molecular Formula

C25H24ClN7O2S

Molecular Weight

522.02

References & Citations

[1]Zhang N, et al. Design, synthesis, and biological evaluation of novel NIK inhibitors for the treatment of inflammatory bowel disease and sepsis. Eur J Med Chem. 2026;302 (Pt 3) :118368.