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COX-2-IN-61

COX-2-IN-61 is an orally active COX-2 inhibitor with an IC50 of 22 µM, also inhibits COX-1 with an IC50 of 43 µM. COX-2-IN-61 exhibits anti-inflammation effects in a Carrageenan induced rat paw edema model, with promising safety profiles. COX-2-IN-61 can be used for the research of inflammation[1].

Product Specifications

UNSPSC

12352100

Target

COX

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=S(C1=CC=C(N2N=C(C3=CC=CS3)C(/C=N/O)=C2)C=C1)(C)=O

Molecular Formula

C15H13N3O3S2

Molecular Weight

347.41

References & Citations

[1]Abdelall EKA, et al. Synthesis and in silico studies of novel thiophene-celecoxib hybrid with excellent cardiotoxicity and nephrotoxicity safety profiles. Eur J Med Chem. 2026;302 (Pt 2) :118297.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-1; COX-2

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