COX-2-IN-61
COX-2-IN-61 is an orally active COX-2 inhibitor with an IC50 of 22 µM, also inhibits COX-1 with an IC50 of 43 µM. COX-2-IN-61 exhibits anti-inflammation effects in a Carrageenan induced rat paw edema model, with promising safety profiles. COX-2-IN-61 can be used for the research of inflammation[1].
Product Specifications
UNSPSC
12352100
Target
COX
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=CC=C(N2N=C(C3=CC=CS3)C(/C=N/O)=C2)C=C1)(C)=O
Molecular Formula
C15H13N3O3S2
Molecular Weight
347.41
References & Citations
[1]Abdelall EKA, et al. Synthesis and in silico studies of novel thiophene-celecoxib hybrid with excellent cardiotoxicity and nephrotoxicity safety profiles. Eur J Med Chem. 2026;302 (Pt 2) :118297.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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