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Cathepsin K-IN-9

Cathepsin K-IN-9 is a selective, potent and orally active Cathepsin K inhibitor with an IC50 of 6.2 nM. Cathepsin K-IN-9 has IC50 > 10000 nM for cathepsin B, L, and S, showing over 1600-fold selectivity. Cathepsin K-IN-9 has excellent safety and metabolic stability.Cathepsin K-IN-9 can be used for the research of osteoporosis[1].

Product Specifications

CAS Number

2361420-28-0

UNSPSC

12352005

Target

Cathepsin

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

CNC1=NC(C#N)=NC2=C1C=C(N2CC(C)(C)C)C(NCC3=CC=C(C=C3)C4=CC=C(C=C4)C5CCN(CC5)C6CC6)=O

Molecular Formula

C35H41N7O

Molecular Weight

575.75

References & Citations

[1]Lee J, et al. Pyrrolopyrimidines: A promising scaffold for the development of novel cathepsin K inhibitors. Eur J Med Chem. 2026;302 (Pt 2) :118323.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cathepsin K

Frequently Asked Questions

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