PROTAC CDK2/4 Degrader-1
PROTAC CDK2/4 Degrader-1 (Compound 5) is a CDK2/4 PROTAC degrader, with its DC50 values for CDK2 and CDK4 both ≤ 10 nM. PROTAC CDK2/4 Degrader-1 exhibits excellent inhibitory activity against cell proliferation in OVCAR3 and T47D cells. PROTAC CDK2/4 Degrader-1 can be used for research on breast cancer and ovarian cancer. (Pink: CDK2/4 ligand ; Blue: CRBN ligand (HY-W593794) ; Black: linker).
Product Specifications
CAS Number
3108138-84-4
UNSPSC
12352005
Target
CDK; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=S(CCCN(CC1)CCC1C(C=C2)=CC3=C2C(C(CC4)C(NC4=O)=O)=NN3C)(N5CCC(NC6=NC=C(OC(F)F)C=N6)CC5)=O
Molecular Formula
C31H40F2N8O5S
Molecular Weight
674.76
References & Citations
[1]Zhiyong Yu, et al. Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 and/or cyclin-dependent kinase 4 via ubiquitin proteasome pathway. WO2025240536.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4; Cereblon
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