PROTAC CDK2/4 Degrader-1

PROTAC CDK2/4 Degrader-1 (Compound 5) is a CDK2/4 PROTAC degrader, with its DC50 values for CDK2 and CDK4 both ≤ 10 nM. PROTAC CDK2/4 Degrader-1 exhibits excellent inhibitory activity against cell proliferation in OVCAR3 and T47D cells. PROTAC CDK2/4 Degrader-1 can be used for research on breast cancer and ovarian cancer. (Pink: CDK2/4 ligand (HY-W1047040) ; Blue: CRBN ligand (HY-W593794) ; Black: linker) [1].

Product Specifications

CAS Number

[3108138-84-4]

UNSPSC

12352005

Target

CDK; PROTACs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=S(CCCN(CC1)CCC1C(C=C2)=CC3=C2C(C(CC4)C(NC4=O)=O)=NN3C)(N5CCC(NC6=NC=C(OC(F)F)C=N6)CC5)=O

Molecular Formula

C31H40F2N8O5S

Molecular Weight

674.76

References & Citations

[1]Zhiyong Yu, et al. Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 and/or cyclin-dependent kinase 4 via ubiquitin proteasome pathway. WO2025240536.