PCC0105005
PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM) . PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine[1].
Product Specifications
CAS Number
2921670-99-5
UNSPSC
12352005
Target
5-HT Receptor; CGRP Receptor; Epigenetic Reader Domain; ERK
Related Pathways
Epigenetics; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
CN(CC1)CCC1C2=CNC3=CC=C(NC(C4=CC(C=C(C5CCN(C(N[C@H](CC6=CC(C)=C(NN=C7)C7=C6)C(N8CCN(C9CCN(C)CC9)CC8)=O)=O)CC5)C(N%10)=O)=C%10C=C4)=O)C=C32
Molecular Formula
C51H63N11O4
Molecular Weight
894.12
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; ERK
Frequently Asked Questions
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