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MRP1-IN-2

MRP1-IN-2 (Compound 21) is a selective MRP1 inhibitor with a relatively weak inhibitory effect on P-gp. MRP1-IN-2 exhibits a strong accumulation effect of calcein, with its EC50 value being 177 nM. MRP1-IN-2 enhances the activity of Doxorubicin on drug-resistant cells. MRP1-IN-2 can be used for the study of multidrug-resistant cancers[1].

Product Specifications

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

NC1=NC(N2CC3(CCOCC3)C2)=C(C(C)CC)C(C4=C(F)C(F)=CC=C4)=N1

Molecular Formula

C21H26F2N4O

Molecular Weight

388.45

References & Citations

[1]Čičak M, et al. The 2-aminopyrimidine ring as a new scaffold for potent MRP1 inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118364.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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