HDAC3 degrader-1

HDAC3 degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. HDAC3 degrader-1 has almost no effect on HDAC1, HDAC2, and HDAC6. HDAC3 degrader-1 inhibits the activation of the NLRP3 inflammasome and reduces the secretion of IL-1β and caspase-1. HDAC3 degrader-1 shows significant efficacy in septic shock and colitis models. HDAC3 degrader-1 can be used in anti-inflammatory research[1].

Product Specifications

UNSPSC

12352005

Target

Caspase; HDAC; Interleukin Related; NOD-like Receptor (NLR)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

FC(CC1)(F)CCN1C([C@@]2(C)CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C5=CC=C4[C@]3([H])C2)=O)=O

Molecular Formula

C36H48F2N2O2

Molecular Weight

578.78

References & Citations

[1]Qin H, et al. Synthesis and biological evaluations of novel 18β-glycyrrhetinic acid derivatives as histone deacetylase 3 degraders with anti-inflammatory effects. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118391.