A2A/A3 agonist-1
A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
Molecular Formula
C18H24N6O3S
Molecular Weight
404.49
References & Citations
[1]Kim SW, et al. Structure-activity relationship analysis of 5'-substituted C2-hexynyl-4'-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118386.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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