UA2239
UA2239 is an antimalarial agent and acyclic nucleoside phosphonate. UA2239 disrupts the essential cGMP-dependent egress pathway by decreasing cGMP levels. UA2239 targets guanylyl cyclase α. UA2239 demonstrates rapid and irreversible inhibitory effects on Plasmodium parasites[1].
Product Specifications
CAS Number
2455422-89-4
UNSPSC
12352005
Target
Guanylate Cyclase; Nucleoside Antimetabolite/Analog; Parasite
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; GPCR/G Protein
Field of Research
Infection
Smiles
O=C1NC(N)=NC2=C1N=CN2CC[C@H](CP(O[Na])(O[Na])=O)O
Molecular Formula
C9H12N5Na2O5P
Molecular Weight
347.18
References & Citations
[1]Ali M, et al. An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP. Sci Adv. 2025 Nov 21;11 (47) :eady2859.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
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