PHGDH-IN-6

PHGDH-IN-6 (Compound L5) is a PHGDH allosteric inhibitor with an IC50 of 2.5 μM. PHGDH-IN-6 can be used for studying diseases related to serine synthesis[1].

Product Specifications

UNSPSC

12352005

Target

Phosphoglycerate Dehydrogenase (PHGDH)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

BrC1=CC(C#CC2=CC=C(NC(C3=C(NC([C@]45C[C@H](NC(OC(C)(C)C)=O)C(O5)=O)=O)C4=CC=C3)=O)C=C2)=CC(C(OC)=O)=C1

Molecular Formula

C33H28BrN3O8

Molecular Weight

674.49

References & Citations

[1]Zhang Y, et al. Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform. J Am Chem Soc. 2025 Dec 3;147 (48) :44396-44405.