PHGDH-IN-6
PHGDH-IN-6 (Compound L5) is a PHGDH allosteric inhibitor with an IC50 of 2.5 μM. PHGDH-IN-6 can be used for studying diseases related to serine synthesis[1].
Product Specifications
UNSPSC
12352005
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
BrC1=CC(C#CC2=CC=C(NC(C3=C(NC([C@]45C[C@H](NC(OC(C)(C)C)=O)C(O5)=O)=O)C4=CC=C3)=O)C=C2)=CC(C(OC)=O)=C1
Molecular Formula
C33H28BrN3O8
Molecular Weight
674.49
References & Citations
[1]Zhang Y, et al. Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform. J Am Chem Soc. 2025 Dec 3;147 (48) :44396-44405.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-179652/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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