NSD2-PWWP1-IN-5
NSD2-PWWP1-IN-5 (Compound 13) is an effective NSD2-PWWP1 inhibitor with a Kd value of 78 nM. NSD2-PWWP1-IN-5 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-5 inhibits the proliferation of U2OS osteosarcoma cells and induces cell cycle arrest and apoptosis. NSD2-PWWP1-IN-5 can be used for the study of osteosarcoma[1].
Product Specifications
CAS Number
217798-45-3
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
O=C(N(C1=CC=C(N)C=C1)[Se]2)C3=C2C=CC=C3
Molecular Formula
C13H10N2OSe
Molecular Weight
289.19
References & Citations
[1]Huang Y, et al. Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2. J Med Chem. 2025 Dec 11;68 (23) :24953-24967.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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