ZG-2686
ZG-2686 is a potent and selective HIF-2α agonist with an EC50 of 0.25 µM. ZG-2686 exhibits selectivity over PHD2. ZG-2686 binds to a specific internal cavity of HIF-2α, forming hydrogen bonds via structural water molecules, which stabilizes the HIF-2α/β heterodimer and enhances transcriptional activity. ZG-2686 synergizes with Vadadustat to upregulate HIF-2α-dependent EPO gene expression both in vitro and in vivo. ZG-2686 can be used for the research of renal anemia[1].
Product Specifications
CAS Number
1795110-22-3
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C(NC1=NNC2=NC=CC=C21)C3=CC=C(Br)C=C3
Molecular Formula
C13H9BrN4O
Molecular Weight
317.14
References & Citations
[1]Gao Y, et al. Discovery of 3- (Arylamido) pyrazolopyridine HIF-2α Agonists and a Codrug Strategy with Prolyl Hydroxylase Inhibition for Synergistic Treatment of Renal Anemia. J Med Chem. 2025;68 (23) :25569-25589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIF
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