Phosphodiesterase-IN-5
Phosphodiesterase-IN-5 is a potent, orally active and selective phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 6.2 nM. Phosphodiesterase-IN-5 shows >1612-fold selectivity over other PDEs. Phosphodiesterase-IN-5 exhibits potent antifibrotic efficacy in a Bleomycin (BLM) -induced murine model of pulmonary fibrosis (PF) by blocking myofibroblast differentiation via the cAMP/PKA/CREB signaling pathway. Phosphodiesterase-IN-5 can be used for the research of PF[1].
Product Specifications
UNSPSC
12352005
Target
Collagen; Interleukin Related; Phosphodiesterase (PDE) ; PKA; TNF Receptor
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(C2CN(C3=NC(C)=C4C=CC=CC4=N3)C2)N=C5C=CC(F)=CN51)N(C6)CCNC76CC7
Molecular Formula
C26H26FN7O
Molecular Weight
471.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10
Frequently Asked Questions
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