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GSTO1-IN-6

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) -induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases[1].

Product Specifications

UNSPSC

12352005

Target

Glutathione S-transferase; Interleukin Related

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CCC[C@@H]1C2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)C=C

Molecular Formula

C16H14F3N3OS

Molecular Weight

353.36

References & Citations

[1]Sun Y, et al. Discovery of Potent, Allosteric GSTO1 Covalent Inhibitors with a New Binding Mode. J Med Chem. 2025;68 (22) :24075-24093.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-1; IL-18

Frequently Asked Questions

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